6533b862fe1ef96bd12c753e

RESEARCH PRODUCT

L’apport thérapeutique des approches protéomiques dans les cancers

A. ChaiebS. RemadiLotfi ChouchaneLotfi ChouchaneBechr HamritaHedi KhairiLauriane KuhnKarim ChahedChristelle GuillierMaria KabbageP. HamannHela Ben Nasr

subject

0303 health sciencesbusiness.industryAutoantibodyObstetrics and GynecologyCancerGeneral Medicinemedicine.diseaseProteomics3. Good health03 medical and health sciences0302 clinical medicineReproductive MedicineTwo dimensional electrophoresisSerum biomarkers030220 oncology & carcinogenesismedicineCancer researchbusinessProtein tumor markersCellular proteins030304 developmental biology

description

Up to now, there are no protein tumor markers with a specificity and sensitivity sufficient to have a utility in prognosis and early diagnosis of cancer. Recent advances in proteomics approaches have led to the identification of novel tumor markers of cancer that may have a utility in screening strategies and treatment. The purpose of the current review is to describe the major advances in cancer proteomics, especially those related to the study of serum biomarkers, immune-related responses (autoantibodies) and alterations in cellular proteins.

https://doi.org/10.1016/j.gyobfe.2010.12.005