6533b862fe1ef96bd12c7558
RESEARCH PRODUCT
ePTFE functionalization for medical applications
Frédéric AuberY. RoinaGuillaume HerlemDidier Hocquetsubject
Materials sciencePolytetrafluoroethylenePolymers and PlasticsBiocompatibilityCell seedingTissue integration02 engineering and technology010402 general chemistry021001 nanoscience & nanotechnology01 natural sciencesCatalysis0104 chemical sciencesElectronic Optical and Magnetic MaterialsBiomaterialschemistry.chemical_compoundColloid and Surface ChemistrychemistryMaterials ChemistrySurface modification0210 nano-technologyBiomedical engineeringdescription
Abstract Polytetrafluoroethylene (PTFE) is a ubiquitous material used in implants and medical devices in general due to its high biocompatibility and inertness; blood vessels, heart, jawbone, nose, eyes, or abdominal wall can benefit from its properties in the case of disease or injury. Its expanded version, ePTFE, is an improved version of PTFE with better mechanical properties, which extend its medical applications. However, ePTFE implants often lack improvement in properties such as antibacterial, antistenosis, or tissue integration properties. Improvements in these properties by several strategies of functionalization for medical purposes are discussed in this review. Covalent and non-covalent bonding are reviewed, including more specifically chemical impregnation, chemical surface modification, autologous vascularization, and cell seeding, which are strategies mainly used for improving the properties of ePTFE and are described in this review.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-06-01 | Materials Today Chemistry |