Synthesis of oligodeoxynucleotides containing diastereomeric dihydrodiol epoxide-N6-deoxyadenosine adducts of polycyclic aromatic hydrocarbons

6533b862fe1ef96bd12c757b

RESEARCH PRODUCT

Synthesis of oligodeoxynucleotides containing diastereomeric dihydrodiol epoxide-N6-deoxyadenosine adducts of polycyclic aromatic hydrocarbons

Albrecht Seidel Thomas Steinbrecher Franz Oesch John J. Stezowski John J. Stezowski Andreas Becker Andreas Becker

subject

Steric effects Oligonucleotide Stereochemistry Organic Chemistry Diastereomer Epoxide Biochemistry Adduct Deoxyribonucleoside chemistry.chemical_compound Deoxyribonucleotide chemistry Deoxyadenosine Drug Discovery Organic chemistry

description

Abstract A generally applicable route is reported for the synthesis of oligodeoxynucleotides which contain structurally defined N 6 -deoxyadenosine adducts, derived from sterically highly hindered dihydrodiol epoxides of polycyclic aromatic hydrocarbons (PAH).

year	journal	country	edition	language
1993-03-01	Tetrahedron Letters

https://doi.org/10.1016/s0040-4039(00)60775-x

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