6533b862fe1ef96bd12c75f4
RESEARCH PRODUCT
Ophiobolin Sesterterpenoids and Pyrrolidine Alkaloids from the Sponge-Derived Fungus Aspergillus ustus
Siegfried DraegerRuangelie Edrada-ebelWenhan LinYao WangHong-bing LiuBarbara SchulzVictor WrayPeter ProkschWerner E.g. MüllerRainer Ebelsubject
biologyMurine lymphomaChemistryStereochemistryOrganic ChemistryFungusbiology.organism_classificationBiochemistryCatalysisCerebrosidePyrrolidineInorganic ChemistrySuberites domunculaSpongechemistry.chemical_compoundBiochemistryAspergillus ustusDrug DiscoveryPhysical and Theoretical ChemistryCytotoxicitydescription
Chemical examination of the fungus Aspergillus ustus isolated from the Mediterranean sponge Suberites domuncula yielded the five new ophiobolin-type sesterterpenoids 1–5 and the two new pyrrolidine alkaloids 6 and 7, together with the known compound aurantiamine and cerebroside D. The structures of the new compounds were unambiguously elucidated on the basis of extensive spectroscopic-data analysis (1D- and 2D-NMR, MS, and UV) and comparison with literature data. All compounds were evaluated for their cytotoxicity against murine lymphoma cell line L5178Y.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-04-01 | Helvetica Chimica Acta |