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RESEARCH PRODUCT

Vaccination in old age: Challenges and promises

Graham PawelecGraham PawelecAnna AielloMattia Emanuela LigottiCalogero Caruso

subject

VaccinationGerontologySettore MED/04 - Patologia Generaleeducation.field_of_studybusiness.industryIntervention (counseling)Populationimmunosenescence older people vaccinationPsychological interventionMedicineImmunosenescenceeducationbusiness

description

Abstract Vaccination is one of the most effective medical interventions ever introduced, preventing millions of cases of infections worldwide every year. However, vaccines are commonly believed to be less effective in providing protection in older adults, due to the perceived decline seen in immunity in this population (“immunosenescence”). Accordingly, this chapter considers how to identify hallmarks of immunosenescence and approach their resolution strategically. It was reviewed potential options for therapeutic intervention to restore appropriate responses to vaccines in older adults.

10.1016/b978-0-12-822569-1.00020-2http://hdl.handle.net/10447/529211