6533b862fe1ef96bd12c779d
RESEARCH PRODUCT
The Effect of Smartphone-Based Cognitive Training on the Functional/Cognitive Markers of Schizophrenia: A One-Year Randomized Study
Ewa MartyniakNapoleon WaszkiewiczJ. PrzybyloArtur PałaszMariusz BorkowskiKrzysztof KrystaMarek KrzystanekKatarzyna SkałackaDavor Mucicsubject
paranoid schizophrenia; cognitive impairment; cognitive training; cognitive markers; functional markers; smartphone application; telephone-based intervention; cognitive remediation therapyParanoid schizophreniamedicine.medical_specialtymedicine.medical_treatmentlcsh:Medicinecognitive markersArticlefunctional markerscognitive training03 medical and health sciences0302 clinical medicinePhysical medicine and rehabilitationMedicineCognitive skillCognitive rehabilitation therapysmartphone applicationparanoid schizophreniacognitive remediation therapycognitive impairmentRehabilitationbusiness.industrytelephone-based interventionlcsh:RCognitionGeneral Medicinemedicine.diseaseCognitive training030227 psychiatrySchizophreniaCognitive remediation therapybusiness030217 neurology & neurosurgerydescription
Background: Cognitive impairment is associated with long-term disability that results in the deterioration of both the social and professional status of individuals with schizophrenia. The impact of antipsychotic therapy on cognitive function is insufficient. Cognitive training is therefore proposed as a tool for cognitive rehabilitation in schizophrenia. In this study we investigated the effect of self-administered cognitive training using a smartphone-based application on the cognitive function of paranoid schizophrenia patients focusing on response time, correct answer rate, incorrect answer rate, and fatigability to check, if these functions can be functional markers of successful cognitive-smartphone rehabilitation. Methods: 1-year multicenter, open-label randomized study was conducted on 290 patients in a state of symptomatic remission. 191 patients were equipped with the full version of the application and conducted cognitive training twice a week. Reference group (n = 99) was provided with a version of the application having only limited functionality, testing the cognitive performance of patients every 6 months. Results: Statistically significant improvement was observed in both the rate of correct answers (by 4.8%, p = 0.0001), and cognitive fatigability (by 2.9%, p = 0.0001) in the study group, along with a slight improvement in the rate of incorrect answers (by 0.9%, p = 0.15). In contrast, the reference group, who performed cognitive training every 6 months, demonstrated no significant changes in any cognitive activities. Conclusions: Cognitive trainings facilitated by a smartphone-based application, performed regularly for a longer period of time are feasible and may have the potential to improve the cognitive functioning of individuals with schizophrenia. Correct answers and cognitive fatigability have potential to be functional markers of successful smartphone-based psychiatric rehabilitations in schizophrenia patients.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-11-16 | Journal of Clinical Medicine |