6533b863fe1ef96bd12c77cd
RESEARCH PRODUCT
Native Mitral Valve Endocarditis Caused by Neisseria elongata subsp. nitroreducens in a Patient with Marfan Syndrome: First Case in Italy and Review of the Literature
Vallone SilvanaGiammanco AnnaArgano VincenzoParrinello RossellaCarità PatriziaGrassedonio EmanueleFasciana TeresaTrapani RenatoVerdecchia MassimoNovo SalvatoreTriolo Fabio OresteMidiri MassimoNovo Giuseppinasubject
0301 basic medicineMarfan syndromePathologymedicine.medical_specialty030106 microbiologyCase Report030204 cardiovascular system & hematologyMicrobiologylcsh:Infectious and parasitic diseases03 medical and health sciencesMitral valve endocarditis0302 clinical medicineMitral valveMedicineEndocarditislcsh:RC109-216Neisseria elongata subsp nitroreducensNeisseria elongatabiologybusiness.industryGeneral MedicineNeisseria elongatabiology.organism_classificationmedicine.diseasemedicine.anatomical_structureInfective endocarditisPositive blood cultureendocarditisbusinessdescription
Neisseria elongata(NE) is an aerobic Gram-negative organism that constitutes part of the commensal human normal oropharyngeal flora. Although previously considered not to be pathogenic, it has been recognized as an occasional cause of significant infections in humans. We report here the first case in Italy of infective endocarditis of a native prolapsing mitral valve in a patient with Marfan syndrome, caused by NE subspeciesnitroreducenswhich has been rarely isolated from clinical specimens. The culprit organism has been confirmed by mass spectrometry directly from the positive blood culture, as previously reported. The amplified gene has been deposited in GenBank under accession number KT591873. In spite of the reported aggressive nature of NE, clinical remission was promptly obtained, there being no requirement for surgery.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 | Case Reports in Infectious Diseases |