Preclinical evidence of new opioid modulators for the treatment of addiction.

6533b863fe1ef96bd12c7860

RESEARCH PRODUCT

Preclinical evidence of new opioid modulators for the treatment of addiction.

Marta Rodríguez-arias José Miñarro Carmen Manzanedo María A. Aguilar

subject

Drug GABA Agents media_common.quotation_subject Narcotic Antagonists Drug Evaluation Preclinical Receptors Opioid mu Pharmacology Receptors Nicotinic Bioinformatics Pharmacotherapy Dopamine Receptors Opioid delta Cannabinoid Receptor Modulators medicine Adrenergic alpha-2 Receptor Agonists Animals Pharmacology (medical)Adverse effect media_common Pharmacology Substance dependence business.industry Addiction Receptors Opioid kappa Antagonist General Medicine medicine.disease Opioid-Related Disorders Rats Substance Withdrawal Syndrome Opioid Receptors Opioid Dopamine Antagonists Female business Excitatory Amino Acid Antagonists medicine.drug

description

Addiction to opiates is one of the most severe forms of substance dependence, and despite a variety of pharmacological approaches to treat it, relapse is observed in a high percentage of subjects. New pharmacological compounds are necessary to improve the outcome of treatments and reduce adverse side effects. Moreover, drugs that act on the opioid system can also be of benefit in the treatment of alcohol or cocaine addiction. AREA COVERED BY THIS REVIEW: Recent preclinical studies of pharmacological agents for the treatment of opiate addiction (2008 to the present date).The reader will be informed of the latest drugs shown in animal models to modify dependence on opiates and the reinforcing effects of these drugs. In addition, reports of the latest studies to test these compounds in models of other drug addictions are reviewed.The classic clinical pharmacotherapy for opiate dependence, involving mu-opioid receptor agonists or antagonists, has not yielded a high success rate in humans. In pharmacotherapy for opioid dependence, new options are emerging and different pharmacological strategies are now being tested.

year	journal	country	edition	language
2010-07-16	Expert opinion on investigational drugs

10.1517/13543784.2010.500612 https://pubmed.ncbi.nlm.nih.gov/20629615

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