6533b863fe1ef96bd12c78be
RESEARCH PRODUCT
Occurrence of Spontaneous Cortical Spreading Depression Is Increased by Blood Constituents and Impairs Neurological Recovery after Subdural Hematoma in Rats.
Daniel JussenDaniel JussenTobias KrämerStephan J TretzelMichaela PlathMichaela PlathOliver KempskiBeat AlessandriHarald KrenzlinHarald Krenzlinsubject
Male030506 rehabilitationTraumatic brain injurymacromolecular substancesHead trauma03 medical and health sciences0302 clinical medicineHematomamedicineAnimalsTissue impedanceIntracranial pressurebusiness.industryCortical Spreading DepressionSubdural hemorrhageBlood ProteinsRecovery of Functionmedicine.diseaseRatsHematoma SubduralParaffinAnesthesiaCortical spreading depressionSevere morbidityNeurology (clinical)0305 other medical sciencebusinessOils030217 neurology & neurosurgerydescription
Acute subdural hemorrhage (ASDH) is common and associated with severe morbidity and mortality. To date, the role of spontaneous cortical spreading depression (sCSD) in exaggerating secondary injury after ASDH, is poorly understood. The present study contains two experimental groups: First, we investigated and characterized the occurrence of sCSD after subdural blood infusion (300 μL) via tissue impedance (IMP) measurement in a rat model. Second, we compared the occurrence and influence of sCSD on lesion growth and neurological deficit in the presence and absence of whole blood constituents. In the first experimental group, three IMP traits could be distinguished after ASDH: no sCSD, recurrent sCSD, and constant elevated IMP (anoxic depolarization [AD]). In the second experimental group, sCSD occurred more often after autologous blood, compared with paraffin oil infusion. Lesion volume 7 days post-ASDH was 27.3 ± 6.8 mm
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-01-15 | Journal of neurotrauma |