6533b863fe1ef96bd12c7966
RESEARCH PRODUCT
Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt
Tobias LucasTill OpatzJule-philipp Dietzsubject
chemistry.chemical_classificationcyclizationfluorinated heterocyclesChemistrypyrimidinesPotassiumOrganic Chemistrychemistry.chemical_elementSalt (chemistry)Substrate (chemistry)Combinatorial chemistryFull Research PaperpyrazolesAmidinelcsh:QD241-441Chemistrychemistry.chemical_compoundlcsh:Organic chemistryfluorineFluorinelcsh:Qlcsh:Sciencedescription
A synthesis of fluorinated pyrimidines under mild conditions from amidine hydrochlorides and the recently described potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-03-01 | Beilstein Journal of Organic Chemistry |