6533b86cfe1ef96bd12c7fa8

RESEARCH PRODUCT

MR-tomographische Messung der diastolischen Relaxation hypertrophierter linker Ventrikel mit Single-slice-multi-phase-Technik

Manfred ThelenJust MHimmelsbach FMichael B. Pitton

subject

PhysicsNuclear magnetic resonanceVentricular functionDiastoleRelaxation velocityEarly diastolicRadiology Nuclear Medicine and imagingMultisliceContraction velocitySystoleMuscle hypertrophy

description

In order to assess diastolic ventricular function in hypertensive patients, a single-slice multiphase sequence was used in order to measure contraction and early diastolic relaxation. There was no difference in the contraction velocity between hypertensives and normals (Vsys. n.r. = 56.1 +/- 13.8% LVDV/s vs. 51.7 +/- 8.6% LVEDV/s, stat, n. sign.). Early diastolic relaxation velocity in hypertensives was reduced as compared with the control group (Vdiast. 1n.r. = 37.9 +/- 13.1% LVEDV/s vs. 47.1 +/- 9.6% LVEDV/s, p < 0.05). There was no linear relation between abnormal relaxation and the extent of myocardial hypertrophy. Hypertensives with myocardial hypertrophy frequently had reduced early diastolic relaxation velocity. Regression analysis for estimating left ventricular volumes derived from single-slice measurements were confirmed by additional multislice measurements. The calculated LVEDV correlated at r = 0.956 with multi-slice measurements and tended to show lower values (LVEDV n.r. = 104.6 +/- 30.8 ml vs. LVEDV = 102.1 +/- 28.8 ml, r = 0.956, p < 0.05). The LVESV was overestimated by the multi-slice technique, the calculated regression volume averaged 23% lower, realistic values (LVESV n.r. = 28.5 +/- 15.3 ml vs. LVESV = 37.1 +/- 15.6 ml, r = 0.887, p < 0.001).

yearjournalcountryeditionlanguage
1993-11-01RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren
https://doi.org/10.1055/s-2008-1032792