6533b86cfe1ef96bd12c8082
RESEARCH PRODUCT
Stimulation of calcium uptake by norepinephrine or high external potassium in human calyces and renal pelvis.
H. NawrathL. Hertlesubject
medicine.medical_specialtyTime FactorsUrologyPotassiumchemistry.chemical_elementStimulationCalciumIn Vitro TechniquesCalcium in biologyKidney CalicesNorepinephrine (medication)NorepinephrineInternal medicineCalcium fluxMolemedicineHumansKidney PelvisMuscle SmoothMiddle AgedStimulation Chemicalmedicine.anatomical_structureEndocrinologychemistryPotassiumCalciumCalcium ChannelsRenal pelvismedicine.drugdescription
The effects of stimulation with either 10 mumol/l norepinephrine or 85 mmol/l extracellular potassium concentration on calcium uptake were studied in muscle strips from human renal calyces and from the renal pelvis. The apparent uptake of calcium under control conditions was essentially complete after 30 min. Stimulation of the muscle strips with norepinephrine or high external potassium significantly (P less than 0.05) increased the calcium uptake over the control values at 30 and 100 min, whereas 45Ca efflux was virtually not affected. It is concluded that the mechanical responses of the muscle strips to norepinephrine or high external potassium correspond with an increased uptake of calcium suggesting that both types of activation are mediated by an increase of intracellular calcium concentration similar to that described in other smooth muscles.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-01-01 | Urological research |