6533b86cfe1ef96bd12c81be
RESEARCH PRODUCT
Identification of a Kd-restricted antigenic peptide encoded by murine cytomegalovirus early gene M84
Rafaela HoltappelsMatthias J. ReddehaseDoris Thomassubject
MuromegalovirusPeptideBiologyMajor histocompatibility complexImmediate-Early ProteinsMiceOpen Reading FramesImmune systemVirologyAnimalsAmino Acid SequenceLymphocyte CountAntigens ViralGenes Immediate-EarlyGeneAntigenic peptidechemistry.chemical_classificationMice Inbred BALB CViral matrix proteinAntigen processingH-2 AntigensVirologyMolecular biologyPeptide FragmentschemistryCytomegalovirus earlybiology.proteinImmunologic MemoryT-Lymphocytes Cytotoxicdescription
The two sister cytomegaloviruses (CMVs), human and murine CMV, have both evolved immune evasion functions that interfere with the major histocompatibility complex class I (MHC-I) pathway of antigen processing and presentation and are effectual in the early (E) phase of virus gene expression. However, studies on murine CMV have shown that E-phase immune evasion is leaky. An E-phase protein involved in immune evasion, namely m04-gp34, was found to simultaneously account for an antigenic peptide presented by the MHC-I molecule Dd. Recent work has demonstrated the induction of protective immunity specific for the E-phase protein M84-p65, one of two murine CMV homologues of the human CMV matrix protein UL83-pp65. In this study, the identification of the MHC-I Kd-restricted M84 peptide 297AYAGLFTPL305 is documented. This peptide is the third antigenic peptide described for murine CMV and the second that escapes immunosubversive mechanisms.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2000-12-01 | Journal of General Virology |