Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

6533b86cfe1ef96bd12c81e2

RESEARCH PRODUCT

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

Rafaela Holtappels Andrea Fick Jeanette Baker Harald Wajant Matthias J. Reddehase Thomas Müller Daniela N. Männel Andreas Brandl Thorsten Winter Viktoria Schäfer Hermann Einsele Carina A. Bäuerlein Axel Seher Jürgen Podlech Sabrina Kraus Johannes Polz Eliana Ribechini Tim Steinfatt Sven Krappmann Janina Kuen Juliane Kums Jorge Amich Andreas Beilhack Hidekazu Nishikii Katja J. Ottmüller Friederike Berberich-siebelt Anja Mottok Manfred B. Lutz Miriam Ritz Ana-laura Jordán-garrote Martin Vaeth Katharina Mattenheimer Christian Brede Stefanie Schwinn Martin Chopra Marlene Biehl

subject

0301 basic medicine Interleukin 2 medicine.medical_treatment Immunology Graft vs Host Disease Mice Inbred Strains chemical and pharmacologic phenomena Hematopoietic stem cell transplantation Biology T-Lymphocytes Regulatory Article Mice 03 medical and health sciences Interleukin 21 immune system diseases hemic and lymphatic diseases medicine Animals Receptors Tumor Necrosis Factor Type II Immunology and Allergy Cytotoxic T cell ddc:610 Research Articles integumentary system Myeloid-Derived Suppressor Cells Hematopoietic Stem Cell Transplantation FOXP3 hemic and immune systems medicine.disease Leukemia ddc:57 030104 developmental biology surgical procedures operative Acute Disease Immunology Myeloid-derived Suppressor Cell Interleukin-2 Female Tumor necrosis factor receptor 2 medicine.drug

description

Activation of TNFR2 with a novel agonist expands T reg cells in vivo and protects allo-HCT recipients from acute GvHD while sparing antilymphoma and antiinfectious properties of transplanted donor T cells.

year	journal	country	edition	language
2015-09-29

10.1084/jem.20151563 https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/18764

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