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RESEARCH PRODUCT
The growing role of precision medicine for the treatment of autoimmune diseases; results of a systematic review of literature and Experts’ Consensus
Roberto GiacomelliAntonella AfeltraElena BartoloniOnorina BerardicurtiMichele BombardieriAlessandra BortoluzziFrancesco CarubbiFrancesco CasoRicard CerveraFrancesco CicciaPaola CiprianiEmmanuel Coloma-bazánFabrizio ContiLuisa CostaSalvatore D'angeloOliver DistlerEugen FeistNathan FoulquierMarco GabiniVanessa GerberRoberto GerliGrembiale Rosa DanielaGiuliana GugginoAriela HoxhaAnnamaria IagnoccoSuzana JordanBashar KahalehKim LauperVasiliki LiakouliEnnio LubranoDomenico MargiottaSaverio NatyLuca NavariniFederico PerosaCarlo PerriconeRoberto PerriconeMarcella PreteJacques-olivier PersCostantino PitzalisRoberta PrioriFelice RivelleseAmelia RuffattiPiero RuscittiRaffaele ScarpaYehuda ShoenfeldGiovanni TrioloAthanasios G. TzioufasSalvatore D’angelosubject
0301 basic medicinerheumatoid arthritismedicine.medical_specialtyantiphospholipid syndrome; precision medicine; primary sjogren's syndrome; rheumatoid arthritis; spondyloarthritides; systemic lupus erythematosus; systemic sclerosis; consensus; humans; precision medicine; autoimmune diseases; lupus erythematosus systemic; sjogren's syndromeConsensusspondyloarthritidesystemic sclerosisImmunologysystemic lupus erythematosuSjogren's Syndrome.Context (language use)Consensuprimary Sjogren's syndromeAutoimmune DiseaseTreatment failureAutoimmune DiseasesNOEfficacy03 medical and health sciences0302 clinical medicineprimary Sjogren’s syndromeAcquired immunodeficiency syndrome (AIDS)systemic lupus erythematosusmedicineImmunology and AllergyHumansLupus Erythematosus SystemicIn patientIntensive care medicineAdverse effect030203 arthritis & rheumatologybusiness.industryPrecision medicinePrecision medicine; antiphospholipid syndrome; primary Sjogren’s syndrome; rheumatoid arthritis; spondyloarthritides; systemic lupus erythematosus; systemic sclerosisEnvironmental exposurerheumatoid arthritimedicine.diseasePrecision medicineantiphospholipid syndrome; Precision medicine; primary Sjogren's syndrome; rheumatoid arthritis; spondyloarthritides; systemic lupus erythematosus; systemic sclerosisspondyloarthritides3. Good health030104 developmental biologySjogren's Syndrome[SDV.IMM]Life Sciences [q-bio]/Immunologybusinesssystemic sclerosiantiphospholipid syndromeHumandescription
International audience; Autoimmune diseases (AIDs) share similar serological, clinical, and radiological findings, but, behind these common features, there are different pathogenic mechanisms, immune cells dysfunctions, and targeted organs. In this context, multiple lines of evidence suggest the application of precision medicine principles to AIDs to reduce the treatment failure. Precision medicine refers to the tailoring of therapeutic strategies to the individual characteristics of each patient, thus it could be a new approach for management of AIDS which considers individual variability in genes, environmental exposure, and lifestyle. Precision medicine would also assist physicians in choosing the right treatment, the best timing of administration, consequently trying to maximize drug efficacy, and, possibly, reducing adverse events. In this work, the growing body of evidence is summarized regarding the predictive factors for drug response in patients with AIDs, applying the precision medicine principles to provide high-quality evidence for therapeutic opportunities in improving the management of these patients.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-02-01 |