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RESEARCH PRODUCT
Multilayer amniotic membrane transplantation in severe ocular graft versus host disease
Manuel Díaz-llopisCristina Peris-martínezA. Navea-tejerinaJosé L. MenezoP. Risueño-reguilloJuan Aurelio Aviñó-martínezsubject
AdultPathologymedicine.medical_specialtyEye diseaseCorneal StromaVisual AcuityGraft vs Host DiseaseCorneal Diseases03 medical and health sciences0302 clinical medicineImmunopathologyMedicineHumansAmnionUnusual caseAmnionRupture Spontaneousbusiness.industryEpithelium CornealGeneral Medicinemedicine.diseaseTransplantationOphthalmologysurgical procedures operativeMembraneGraft-versus-host diseasemedicine.anatomical_structure030221 ophthalmology & optometryFemaleBone marrowbusiness030217 neurology & neurosurgeryFollow-Up Studiesdescription
To clarify the usefulness of multilayer amniotic membrane transplantation in an unusual case of calcareous corneal degeneration in a patient with graft-versus-host disease.A 20-year-old Caucasian woman had bilateral calcareous corneal degeneration of one year of evolution, secondary to graft-versus-host disease. Treatment for both eyes with topical steroids and antibiotic ointment was not successful. Right eye had a spontaneous corneal perforation, and a three-layer circle amniotic membrane graft was applied to the whole cornea.During a follow-up period of 20 months we observed stability of the corneal epithelium and stroma. The amniotic membrane-covered area showed rapid epithelization, reduced inflammation and suppressed fibrosis formation.Multilayer amniotic membrane transplantation may be considered an alterantive for reconstructing the ocular surface in a patient with severe dry eyes and calcareous corneal degeneration, even with little perforation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-01-01 |