6533b86cfe1ef96bd12c8378
RESEARCH PRODUCT
Selective electrochemical discrimination between dopamine and phenethylamine-derived psychotropic drugs using electrodes modified with an acyclic receptor containing two terminal 3-alkoxy-5-nitroindazole rings.
Vicente J. AránAntonio DoménechNoemí MontoyaBeatriz MuroPilar NavarroEnrique García-españasubject
PhenethylamineIndazolesStereochemistryDopamineMescalineElectrochemistryBiochemistryMedicinal chemistryAnalytical ChemistryMethamphetaminechemistry.chemical_compoundDopaminePhenethylaminesElectrochemistrymedicineEnvironmental ChemistryAmphetamineElectrodesSpectroscopyMescalinePsychotropic DrugsAmphetaminesMeth-Electrochemical TechniquesMethamphetamineCarbonAmphetaminechemistryAlkoxy groupmedicine.drugdescription
Electrochemical discrimination between dopamine and psychotropic drugs which have in common a skeletal structure of phenethylamine, can be obtained using acyclic receptors L(1) and L(2), containing two terminal 3-alkoxy-5-nitroindazole rings. Upon attachment to graphite electrodes, L(1) and L(2) exhibit a well-defined, essentially reversible solid state electrochemistry in contact with aqueous media, based on electrolyte-assisted reduction processes involving successive cation and anion insertion/binding. As a result, a distinctive, essentially Nernstian electrochemical response is obtained for phenethylammonium ions of methamphetamine (METH), p-methoxyamphetamine (PMA), amphetamine (AMPH), mescaline (MES), homoveratrylamine (HOM), phenethylamine (PEA) and dopamine (DA) in aqueous media.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-04-22 | The Analyst |