Features Associated with Recurrence Beyond 5 Years After Nephrectomy and Nephron-Sparing Surgery for Renal Cell Carcinoma: Development and Internal Validation of a Risk Model (PRELANE score) to Predict Late Recurrence Based on a Large Multicenter Database (CORONA/SATURN Project).

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RESEARCH PRODUCT

Features Associated with Recurrence Beyond 5 Years After Nephrectomy and Nephron-Sparing Surgery for Renal Cell Carcinoma: Development and Internal Validation of a Risk Model (PRELANE score) to Predict Late Recurrence Based on a Large Multicenter Database (CORONA/SATURN Project).

S Brookman May M May Sf Shariat E Xylinas C Stief R Zigeuner T Chromecki M Burger Wf Wieland L Cindolo L Schips O De Cobelli Bernardo Maria Cesare Rocco C De Nunzio B Feciche M Truss C Gilfrich S Pahernik M Hohenfellner S Zastrow Mp Wirth G Novara M Carini A Minervini C Simeone A Antonelli V Mirone N Longo A Simonato G Carmignani V Ficarra Members Of The Corona Project The Saturn Project

subject

Male Time Factors Databases Factual Lymphovascular invasion medicine.medical_treatment Predictive Value of Test computer.software_genre Nephrectomy Risk model Decision Support Technique Risk Factors Retrospective Studie Renal cell carcinoma Odds Ratio late recurrence nephrectomy Medicine Multivariate Analysi Framingham Risk Score Database Kidney Neoplasm renal carcinoma Prognostic parameters Middle Aged Nephrectomy Kidney Neoplasms Treatment Outcome Lymphatic Metastasis Female Radiology Nephron sparing surgery Prognostic parameter Human medicine.medical_specialty renal cell carcinoma recurrence Logistic Model Time Factor Urology Reproducibility of Result Late recurrence cancer-specific mortality risk score Risk Assessment Disease-Free Survival Decision Support Techniques cancer-specific mortality; late recurrence; nephrectomy; prognostic parameters; renal cell carcinoma; risk score Predictive Value of Tests Late Recurrence Humans Internal validation Carcinoma Renal Cell Proportional Hazards Models Retrospective Studies Aged Neoplasm Staging Chi-Square Distribution business.industry Proportional hazards model Risk Factor renal cell carcinoma; recurrence; Cancer-specific mortality; Late recurrence; Nephrectomy; Prognostic parameters; Risk score Cancer-specific mortality Reproducibility of Results Lymphatic Metastasi Retrospective cohort study Odds ratio prognostic parameters medicine.disease Confidence interval Logistic Models Multivariate Analysis Proportional Hazards Model Risk score Neoplasm Grading Neoplasm Recurrence Local business computer Cancer-specific mortality; Late recurrence; Nephrectomy; Prognostic parameters; Renal cell carcinoma; Risk score

description

Background: Approximately 10-20% of recurrences in patients treated with nephrectomy for renal cell carcinoma (RCC) develop beyond 5 yr after surgery (late recurrence). Objective: To determine features associated with late recurrence. Design, setting, and participants: A total of 5009 patients from a multicenter database comprising 13 107 RCC patients treated surgically had a minimum recurrence-free survival of 60 mo (median follow-up [FU]: 105 mo [range: 78-135]); at last FU, 4699 were disease free (median FU: 103 mo [range: 78-134]), and 310 patients (6.2%) experienced disease recurrence (median FU: 120 mo [range: 93-149]). Interventions: Patients underwent radical nephrectomy or nephron-sparing surgery. Outcome measurements and statistical analysis: Multivariable regression analyses identified features associated with late recurrence. Cox regression analyses evaluated the association of features with cancer-specific mortality (CSM). Results and limitations: Lymphovascular invasion (LVI) (odds ratio [OR]: 3.07; p pT1 (OR: 2.28; p 1: 2 points), and a risk score was developed for the prediction of late recurrences. The calculated values (0 points: Late recurrence risk 3.1%; 1-3 points: 8.4%; 4-5 points: 22.1%) resulted in a good-, intermediate- and poor-prognosis group (area under the curve value for the model: 70%; 95% confidence interval, 67-73). Multivariable Cox regression analysis showed LVI (HR: 2.75; p pT1 are independent predictors of late recurrence after at least 5 yr from surgery in patients with RCC. We developed a risk score that allows for prognostic stratification and individualized aftercare of patients with regard to counseling, follow-up scheduling, and clinical trial design. © 2012 European Association of Urology.

year	journal	country	edition	language
2014-04-08

10.1016/j.eururo.2012.06.030 https://hdl.handle.net/11380/1128561