6533b86cfe1ef96bd12c86e5
RESEARCH PRODUCT
Identifying modularity structure of a genetic network in gene expression profile data
Luigi AugugliaroAngelo Mineosubject
Settore SECS-S/01 - StatisticaGaussian graphical models modularity differentially expressed genes.description
Aim of this paper is to define a new statistical framework to identify central modules in Gaussian Graphical Models (GGMs) estimated by gene expression data measured on a sample of patients with negative molecular response to Imatinib. Imanitib is a drug used to treat certain types of cancer that in many statistical studies has been reported to have a significant clinical effect on chronic myeloid leukemia (CML) in chronic phase as well as in blast crisis. For central module in a GGM we intend a module containing genes that are defined differently expressed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-01-01 |