6533b86cfe1ef96bd12c8745
RESEARCH PRODUCT
Synthesis and antiproliferative activity of [1,2,4] triazino[4,3-a]indoles
P. BarrajaP. DianaAntonino LauriaA. MontalbanoA. M. AlmericoG. DattoloG. Cirrincionesubject
antiproliferative activityIndolesTriazinesCell Line TumorNeoplasms2-diazoindoletriazinoindoleHumansAntineoplastic AgentsDrug Screening Assays AntitumorSettore CHIM/08 - Chimica Farmaceuticadescription
A series of [1, 2, 4triazino[4,3-a]indoles was prepared in good yield by reacting 2-diazo-3-ethoxycarbonylindole with methylene active compounds. Derivatives of the title ring system were tested against a panel of 60 human tumor cell lines, and showed inhibitory activity against a wide range of cancer cell lines at micromolar concentration.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-03-02 |