0000000001172499

AUTHOR

G. Dattolo

showing 2 related works from this author

3-Diazopyrroles—IV. Structure determination using 13C NMR spectroscopy

1990

Abstract On the basis of the 13 C NMR chemical shifts, it is proposed that, although b is the major canonical structure, structure c , in which a negative charge resides at C-3, provides an important contribution to the resonance stabilization of the 3-diazopyrroles, 1–4 .

Deuterium NMRCrystallographyChemistryCarbon-13 NMR satelliteGeneral EngineeringAnalytical chemistryNuclear magnetic resonance spectroscopy of nucleic acidsNuclear magnetic resonance crystallographyNuclear magnetic resonance spectroscopyFluorine-19 NMRCarbon-13 NMRTwo-dimensional nuclear magnetic resonance spectroscopySpectrochimica Acta Part A: Molecular Spectroscopy
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Synthesis and antiproliferative activity of [1,2,4] triazino[4,3-a]indoles

2005

A series of [1, 2, 4triazino[4,3-a]indoles was prepared in good yield by reacting 2-diazo-3-ethoxycarbonylindole with methylene active compounds. Derivatives of the title ring system were tested against a panel of 60 human tumor cell lines, and showed inhibitory activity against a wide range of cancer cell lines at micromolar concentration.

antiproliferative activityIndolesTriazinesCell Line TumorNeoplasms2-diazoindoletriazinoindoleHumansAntineoplastic AgentsDrug Screening Assays AntitumorSettore CHIM/08 - Chimica Farmaceutica
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