6533b86cfe1ef96bd12c8a8c
RESEARCH PRODUCT
Regulation of mRNA transport, localization and translation in the nervous system of mammals (Review).
Gabriella SchieraCarlo Maria Di LiegroItalia Di Liegrosubject
Untranslated regionNeurogenesisnon-coding RNAneuronsRNA-binding proteinsRNA-binding proteinBiologyRNA TransportTranscription (biology)Settore BIO/10 - BiochimicaGeneticsProtein biosynthesisAnimalsHumansMRNA transportCoding regionRNA MessengerSettore BIO/06 - Anatomia Comparata E CitologiaRNA metabolismMammalsGeneticsMessenger RNAsynaptic plasticitynervous systemRNAArticlesGeneral Medicinepost-transcriptional regulation RNA-binding proteins neurons nervous system synaptic plasticity RNA metabolism mRNA pre-localization non-coding RNA.Cell biologyProtein BiosynthesismRNA pre-localizationpost-transcriptional regulationdescription
Post-transcriptional control of mRNA trafficking and metabolism plays a critical role in the actualization and fine tuning of the genetic program of cells, both in development and in differentiated tissues. Cis-acting signals, responsible for post-transcriptional regulation, reside in the RNA message itself, usually in untranslated regions, 5' or 3' to the coding sequence, and are recognized by trans-acting factors: RNA-binding proteins (RBPs) and/or non-coding RNAs (ncRNAs). ncRNAs bind short mRNA sequences usually present in the 3'-untranslated (3'-UTR) region of their target messages. RBPs recognize specific nucleotide sequences and/or secondary/tertiary structures. Most RBPs assemble on mRNA at the moment of transcription and shepherd it to its destination, somehow determining its final fate. Regulation of mRNA localization and metabolism has a particularly important role in the nervous system where local translation of pre-localized mRNAs has been implicated in developing axon and dendrite pathfinding, and in synapse formation. Moreover, activity-dependent mRNA trafficking and local translation may underlie long-lasting changes in synaptic efficacy, responsible for learning and memory. This review focuses on the role of RBPs in neuronal development and plasticity, as well as possible connections between ncRNAs and RBPs.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-01-21 |