Good clinical practice for the use of vasopressor and inotropic drugs in critically ill patients: state-of-the-science and expert consensus

6533b86cfe1ef96bd12c8ac7

RESEARCH PRODUCT

Good clinical practice for the use of vasopressor and inotropic drugs in critically ill patients: state-of-the-science and expert consensus

Andrea Cortegiani Massimo Girardis Giuseppe Foti Massimo Antonelli Luigi Tritapepe Giacomo Grasselli Luigia Scudeller Elvio De Blasio Elena Bignami Sabino Scolletta Francesco Forfori Maurizio Cecconi Andrea Carsetti Stefano Romagnoli Katia Donadello Abele Donati Fabio Guarracino

subject

Inotrope medicine.medical_specialty Consensus Critical Care Critical Illness MEDLINE shock Cardiotonic Agents Cardiotonic agents Vasoconstrictor agents Cardiogenic shock; Cardiotonic agents; Septic shock; Vasoconstrictor agents 03 medical and health sciences 0302 clinical medicine Vasoconstrictor agents 030202 anesthesiology Septic shock Intensive care medicine Humans Vasoconstrictor Agents Intensive care medicine Cardiogenic shock business.industry Septic shock Cardiogenic shock 030208 emergency & critical care medicine medicine.disease Anesthesiology and Pain Medicine Pharmaceutical Preparations Shock (circulatory)Good clinical practice medicine.symptom business Cardiotonic agents

description

Vasopressors and inotropic agents are widely used in critical care. However, strong evidence supporting their use in critically ill patients is lacking in many clinical scenarios. Thus, the Italian Society of Anesthesia and Intensive Care (SIAARTI) promoted a project aimed to provide indications for good clinical practice on the use of vasopressors and inotropes, and on the management of critically ill patients with shock. A panel of 16 experts in the field of intensive care medicine and hemodynamics has been established. Systematic review of the available literature was performed based on PICO questions. Basing on available evidence, the panel prepared a summary of evidences and then wrote the clinical questions. A modified semi-quantitative RAND/UCLA appropriateness method has been used to determine the appropriateness of specific clinical scenarios. The panel identified 29 clinical questions for the use of vasopressors and inotropes in patients with septic shock and cardiogenic shock. High level of agreement exists among the panel members about appropriateness of inotropes/vasopressors' use in patients with septic shock and cardiogenic shock.

year	journal	country	edition	language
2021-01-01

10.23736/s0375-9393.20.14866-1 http://hdl.handle.net/11365/1131288