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RESEARCH PRODUCT
Prevalence of late-onset 11 β-hydroxylase-deficiency in hirsute patients
M. PaganoAlberto JanniEnrico CarminaG. Maliziasubject
AdultHirsutismendocrine systemmedicine.medical_specialtyTime FactorsAdolescentEndocrinology Diabetes and MetabolismLate onset11-Deoxycortisolchemistry.chemical_compoundBasal (phylogenetics)EndocrinologyInternal medicinemedicineHumansSicilyActh stimulationhirsutismAdrenal Hyperplasia Congenitalbusiness.industryHydroxylase deficiencyHyperandrogenismmedicine.diseaseEndocrinologychemistrySteroid HydroxylasesFemalebusinessHormonedescription
Serum levels of 11-deoxycortisol were determined in 182 hirsute women. Three patients presented high basal 11-deoxycortisol levels and an exaggerated response of this steroid to ACTH stimulation. A fourth patient had normal basal 11-deoxycortisol but was hyperresponsive to ACTH stimulation. Therefore diagnosis of late-onset 11 beta-hydroxylase deficiency was made in 4 out of 182 hirsute women with a prevalence of 2.2% in the group studied. In these patients, clinical findings and other hormonal patterns were not different from those of other women suffering from hirsutism.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1988-09-01 | Journal of Endocrinological Investigation |