6533b86cfe1ef96bd12c8d95
RESEARCH PRODUCT
DRUG DELIVERY FROM MUCOADHESIVE DISKS BASED ON A PHOTO-CROSS-LINKABLE POLYASPARTAMIDE DERIVATIVE
Gaetano GiammonaGiovanna PitarresiDelia MandracchiaPaola PierroGiuseppe Tripodosubject
Glycidyl methacrylateMaterials sciencePolyaspartamide Glycidyl methacrylate Hydrogels Mucoadhesion Amoxicillin Drug releasedigestive oral and skin physiologyPharmaceutical ScienceBiodegradable polymerDosage formchemistry.chemical_compoundchemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoDrug deliveryPolymer chemistrySelf-healing hydrogelsmedicineMucoadhesionSwellingmedicine.symptomAntibacterial agentNuclear chemistrydescription
Disks for local delivery of amoxicillin to the buccal or gastric cavity were prepared using as starting polymer a polyaspartamide derivative. In particular, α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA) was derivatized with glycidyl methacrylate (GMA) in order to synthesize PHG, a photo-cross-linkable and biodegradable polymer that gives rise to the formation of a chemical hydrogel (PHG-UV) by UV irradiation. This hydrogel was shaped as disks whose mucoadhesive properties have been confirmed by swelling measurements in phosphate buffer/citric acid solution at pH 7.0 in the presence of various concentrations of mucin. Swelling ability of PHG-UV disks was also evaluated in simulated salivary and gastric fluids. Amoxicillin was soaked into PHG-UV disks and its release was evaluated in simulated buccal and gastric conditions. The results obtained showed that the prepared disks also provide a reduction of the drug degradation in acidic medium.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2005-01-01 |