Oxidative stress is related to frailty, not to age or sex, in a geriatric population: lipid and protein oxidation as biomarkers of frailty.

6533b86cfe1ef96bd12c8dad

RESEARCH PRODUCT

Oxidative stress is related to frailty, not to age or sex, in a geriatric population: lipid and protein oxidation as biomarkers of frailty.

Gloria Olaso-gonzalez Francisco José García-garcía Mar Dromant Marta Ingles Juan Gambini Consuelo Borras Leocadio Rodríguez-mañas José A. Carnicero Jose Viña

subject

Gerontology Male medicine.medical_specialty Protein Carbonylation Frail Elderly Context (language use)Protein oxidation medicine.disease_cause Cohort Studies chemistry.chemical_compound Sex Factors Internal medicine Malondialdehyde Blood plasma medicine Humans Aged Aged 80 and over business.industry Confounding Age Factors Proteins Malondialdehyde Lipid Metabolism Oxidative Stress Endocrinology Cross-Sectional Studies chemistry Female Geriatrics and Gerontology business Oxidative stress Biomarkers Cohort study

description

Objectives: To ascertain whether indicators of oxidative damage to lipids (malondialdehyde (MDA)) and proteins (protein carbonylation) are biomarkers of frailty, after adjusting for age, sex, and other possible confounders. Design: Cross-sectional cohort study. Setting: Community. Participants: Toledo Study for Healthy Aging participants (N = 742, aged 65–95), classified as frail (n = 54), prefrail (n = 278) and nonfrail (n = 410) according to the Fried criteria. Measurements: Blood plasma was obtained using centrifugation (1,500 G, 15 minutes) and immediately frozen at −80°C. Plasma lipid peroxidation was determined by measuring the MDA formed from lipoperoxides using high-performance liquid chromatography and protein carbonylation was measured using Western blot. Results: Age- and sex-adjusted levels of lipoperoxides (measured as MDA) and protein carbonylation in plasma proved to be related to frailty, even after including possible independent confounders. Conclusion: Circulating oxidative damage biomarkers, such as MDA and protein carbonylation, are related to frailty and not to age or sex. These parameters may be considered as potential biomarkers of frailty in the context of a multidisciplinary health-promoting approach for older adults.

year	journal	country	edition	language
2014-06-26	Journal of the American Geriatrics Society

10.1111/jgs.12876 https://pubmed.ncbi.nlm.nih.gov/25900512