6533b86dfe1ef96bd12c94fe
RESEARCH PRODUCT
Light on the molecular and cellular mechanisms of bicuspid aortic valve to unveil phenotypic heterogeneity
Balistrericarmela RitaGiacomo FratiSebastiano SciarrettaElena Cavarrettasubject
molecular and cellular mechanismbicuspid aortic valvethoracicphenotypeprecision medicineaortic aneurysm thoracic; aortic valve; biomarkers; heart valve diseases; humans; precision medicine; genetic heterogeneity; phenotypeBiologyBioinformaticsheart valve diseasesgenetic heterogeneityAortic aneurysmBicuspid aortic valveBicuspid Aortic Valve DiseasemedicineSettore MED/05 - Patologia ClinicahumansMolecular BiologyAortic Aneurysm ThoracicGenetic heterogeneitybiomarkersmedicine.diseasePrecision medicineaortic valvePhenotypeCardiology and Cardiovascular Medicineaortic aneurysmdescription
Research on bicuspid aortic valve disease (BAV) and related complications has grown in an exponential manner in the last decades. However, the current knowledge of the mechanisms underlying the development of this disease is still limited, since all clinical and surgical studies on BAV mainly focused their objects on its major vascular complications, such as ascending aortic aneurysms and dissection. It is now clear that a better understanding of the pivotal molecular and cellular pathophysiological aspects of bicuspid valve aortopathy, including natural history, phenotypic expression, histology, cellular mechanisms and pathways, is critical for improving its clinical management. This changing paradigm has clearly emerged in the recently released American Association for Thoracic Surgery (AATS) consensus guidelines focusing on bicuspid aortic valve-related aortopathy, which covered all major aspects of BAV
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-01-01 | Journal of Molecular and Cellular Cardiology |