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RESEARCH PRODUCT

In vitro antioxidant properties, DNA damage protective activity, and xanthine oxidase inhibitory effect of cajaninstilbene acid, a stilbene compound derived from pigeon pea [Cajanus cajan (L.) Millsp.] leaves.

Mei YangYu-jie FuYuangang ZuThomas EfferthYu KongNan WuXiao PengZhiwei Yang

subject

DNA BacterialXanthine OxidaseAntioxidantDNA damagemedicine.medical_treatmentAllopurinolResveratrolBiologyAntioxidantsNitric oxideLipid peroxidationchemistry.chemical_compoundCajanusStilbenesmedicineHumansEnzyme InhibitorsXanthine oxidasechemistry.chemical_classificationPlant ExtractsAntimutagenic AgentsGeneral ChemistrySalicylatesPlant LeavesEnzymechemistryBiochemistryGeneral Agricultural and Biological Sciencesmedicine.drugDNA Damage

description

The antioxidant properties, DNA damage protective activities, and xanthine oxidase (XOD) inhibitory effect of cajaninstilbene acid (CSA) derived from pigeon pea leaves were studied in the present work. Compared with resveratrol, CSA showed stronger antioxidant properties, DNA damage protective activity, and XOD inhibition activity. The IC(50) values of CSA for superoxide radical scavenging, hydroxyl radical scavenging, nitric oxide scavenging, reducing power, lipid peroxidation, and XOD inhibition were 19.03, 6.36, 39.65, 20.41, 20.58, and 3.62 μM, respectively. CSA possessed good protective activity from oxidative DNA damage. Furthermore, molecular docking indicated that CSA was more potent than resveratrol or allopurinol to interact with the active site of XOD (calculated free binding energy: -229.71 kcal mol(-1)). On the basis of the results, we conclude that CSA represents a valuable natural antioxidant source and may potentially be applicable in health food industry.

yearjournalcountryeditionlanguage
2010-12-07Journal of agricultural and food chemistry
10.1021/jf103970bhttps://pubmed.ncbi.nlm.nih.gov/21128613