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RESEARCH PRODUCT
Granulysin‐Dependent Killing of Intracellular and ExtracellularMycobacterium tuberculosisby Vγ9/Vδ2 T Lymphocytes
Juraj IvanyiGuido SireciMarie Alix PeyratFrancesco DieliMarita Troye-blombergNadia CaccamoJean-jacques FourniéAlfredo SalernoAlfredo SalernoMarc BonnevilleAlan M. Krenskysubject
Antigens Differentiation T-LymphocyteCytotoxicity ImmunologicTuberculosisReceptors Antigen T-Cell alpha-betaT-LymphocytesBiologyMicrobiologyMycobacterium tuberculosisExtracellularmedicineHumansTuberculosisImmunology and AllergyMacrophageGranulysinMacrophagesReceptors Antigen T-Cell gamma-deltaMycobacterium tuberculosisT lymphocytemedicine.diseasebiology.organism_classificationInfectious DiseasesPerforinImmunologybiology.proteinIntracellulardescription
Contribution of Vgamma9/Vdelta2 T lymphocytes to immune protection against Mycobacterium tuberculosis is still a matter of debate. It was reported earlier that Vgamma9/Vdelta2 T lymphocytes kill macrophages harboring live M. tuberculosis through a granule-dependent mechanism that results in killing of intracellular bacilli. This study found that Vgamma9/Vdelta2 T lymphocytes reduce the viability of both extracellular and intracellular M. tuberculosis. Granulysin and perforin, both detected in Vgamma9/Vdelta2 T lymphocytes, play a major role, which indicates that Vgamma9/Vdelta2 T lymphocytes directly contribute to a protective host response against M. tuberculosis infection.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-10-15 | The Journal of Infectious Diseases |