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RESEARCH PRODUCT
CpG-Loaded Multifunctional Cationic Nanohydrogel Particles as Self-Adjuvanting Glycopeptide Antitumor Vaccines
Natascha StergiouHorst KunzBjörn PalitzschLutz NuhnEdgar SchmittSebastian HartmannBastian GerlitzkiRudolf ZentelMarkus Glaffigsubject
medicine.medical_treatmentMolecular Sequence DataBiomedical EngineeringPharmaceutical ScienceEnzyme-Linked Immunosorbent Assaymedicine.disease_causeCancer VaccinesHydrogel Polyethylene Glycol DimethacrylateEpitopeBiomaterialsAdjuvants ImmunologicCationsmedicineAnimalsHumansAmino Acid SequenceReceptorMice Inbred BALB COligonucleotideToxinChemistryGlycopeptidesGlycopeptideOligodeoxyribonucleotidesCpG siteImmunologyCancer researchNanoparticlesAdjuvantConjugatedescription
Self-adjuvanting antitumor vaccines by multifunctional cationic nanohydrogels loaded with CpG. A conjugate consisting of tumor-associated MUC1-glycopeptide B-cell epitope and tetanus toxin T-cell epitope P2 is linked to cationic nanogels. Oligonucleotide CpG complexation enhances toll-like receptor (TLR) stimulated T-cell proliferation and rapid immune activation. This co-delivery promotes induction of specific MUC1-antibodies binding to human breast tumor cells without external adjuvant.
year | journal | country | edition | language |
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2014-10-18 | Advanced Healthcare Materials |