6533b86dfe1ef96bd12c968e

RESEARCH PRODUCT

CpG-Loaded Multifunctional Cationic Nanohydrogel Particles as Self-Adjuvanting Glycopeptide Antitumor Vaccines

Natascha StergiouHorst KunzBjörn PalitzschLutz NuhnEdgar SchmittSebastian HartmannBastian GerlitzkiRudolf ZentelMarkus Glaffig

subject

medicine.medical_treatmentMolecular Sequence DataBiomedical EngineeringPharmaceutical ScienceEnzyme-Linked Immunosorbent Assaymedicine.disease_causeCancer VaccinesHydrogel Polyethylene Glycol DimethacrylateEpitopeBiomaterialsAdjuvants ImmunologicCationsmedicineAnimalsHumansAmino Acid SequenceReceptorMice Inbred BALB COligonucleotideToxinChemistryGlycopeptidesGlycopeptideOligodeoxyribonucleotidesCpG siteImmunologyCancer researchNanoparticlesAdjuvantConjugate

description

Self-adjuvanting antitumor vaccines by multifunctional cationic nanohydrogels loaded with CpG. A conjugate consisting of tumor-associated MUC1-glycopeptide B-cell epitope and tetanus toxin T-cell epitope P2 is linked to cationic nanogels. Oligonucleotide CpG complexation enhances toll-like receptor (TLR) stimulated T-cell proliferation and rapid immune activation. This co-delivery promotes induction of specific MUC1-antibodies binding to human breast tumor cells without external adjuvant.

https://doi.org/10.1002/adhm.201400460