6533b86dfe1ef96bd12c96fd
RESEARCH PRODUCT
The Genome of the Sea Urchin Strongylocentrotus purpuratus
Amro HamdounVirginia BrocktonHuyen DinhQiang TuRichard O. HynesMaria Ina ArnoneWratko HlavinaL. Courtney SmithMariano A. LozaDavid R. BurgessMatthew P. HoffmanFlorian RaibleQiu Autumn YuanGeoffrey OkwuonuMark Y. TongJennifer HumeDonna MaglottManisha GoelOlivier FedrigoManuel L. Gonzalez-garayCelina E. JulianoJudith HernandezGary M. WesselWilliam F. MarzluffAudrey J. MajeskeChristian GacheLouise DuloquinXingzhi SongFrançois LaprazFowler JAlexandre SouvorovJared V. GoldstoneGeorgia PanopoulouSandra HinesKyle M. JudkinsClay DavisChristine G. ElsikChristine G. ElsikPaul KittsMariano Loza-collGreg WrayTaku HibinoEric RöttingerAllison M. ChurcherAnnamaria LocascioArcady MushegianArcady MushegianMasashi KinukawaAnna ReadeKatherine M. BuckleyI. R. GibbonsBert GoldAleksandar MilosavljevicDavid EpelVictor D. VacquierVictor D. VacquierLing Ling PuVincenzo CavalieriErin L. AllgoodLan ZhangLynne V. NazarethConstantin N. FlytzanisConstantin N. FlytzanisIan BosdetYi-hsien SuZeev PancerMatthew L. RoweRobert C. AngererDavid R. McclayWilliam H. KleinRachel F. GrayJulian L. WongShunsuke YaguchiRobert BelléRobert BelléAaron J. MackeyAaron J. MackeyHerath Jayantha GunaratneKarl Frederik BergeronBruce P. BrandhorstGreg MurrayAvis H. CohenStephanie BellKristin Tessmar-raibleIan K. TownleyBertrand CossonBertrand CossonThomas D. GlennJongmin NamCynthia A. BradhamMichael DeanJoseph ChackoAnthony J. RobertsonMargherita BrannoValeria MatrangaK. James DurbinEsther MirandaLili ChenEran ElhaikRobert D. BurkeRita A. WrightPaola OliveriSandra L. LeeGary W. MoyAlexander E PrimusShawn S. MccaffertyCristina CalestaniDavid A. GarfieldErica SodergrenKaren WilsonKaren WilsonJoel SmithMarco A. MarraCynthia MessierJulia MoralesJulia MoralesKim D. PruittRachel ThornRachel GillJohn S. TaylorMark E. HahnVictor SapojnikovMeredith Howard-ashbyLynne M. AngererMaurice R. ElphickKathy R. FoltzAnne Marie GenevièreAnne Marie GenevièreJustin T. ReeseBlanca E. GalindoKim C. WorleyAndrew LeoneGlen HumphreyKevin BerneyOlga ErmolaevaGeorge MinerDavid P. TerwilligerElly Suk Hen ChowLora LewisDan GraurKaren WilsonC. Titus BrownGerard ManningKevin J. PetersonAngela JolivetMichele K. AndersonFrancesca RizzoEkaterina VoroninaThierry LepageGiorgio MatassiAntonio Fernandez-guerraAntonio Fernandez-guerraMamoru NomuraCharles A. WhittakerJames R.r. WhittleJames A. CoffmanGeorge M. WeinstockMohammed M. IdrisAshlan M. MusanteSebastian D. FugmannKatherine D. WaltonSorin IstrailShu-yu WuCerrissa HamiltonJonah CoolJacqueline E. ScheinStacey M. CurryAthula WikramanaykeSeth CarbonneauBlair J. RossettiChristopher E. KillianMelissa J. LandrumMelissa J. LandrumAmanda P. RawsonJenifer C. CroceRyan C. RangeRahul SatijaJohn J. StegemanYufeng ShenCavit AgcaTerry GaasterlandRocky CheungTakae KiyamaNikki AdamsNikki AdamsJonathan P. RastRobert Piotr OlinskiAndrew CreeMark ScallyShuguang LiangDavid A. ParkerRebecca ThomasonRebecca ThomasonGretchen E. HofmannMichelle M. RouxRonghui XuRobert A. ObarEnrique ArboledaOdile Mulner-lorillonShannon Dugan-rochaDavid J. BottjerGabriele AmoreManoj P. SamantaWaraporn TongprasitVéronique DubocLa Ronda JacksonFred H. WiltViktor StolcAnna T. NeillMichael RaischPei Yun LeeJia L. SongMargaret MorganBrian T. LivingstonSofia HussainZheng WeiBryan J. ColeTonya F. SeversonVictor V. SolovyevFinn HallböökDonna M. MuznyChristine A. ByrumChristine A. ByrumAlbert J. PoustkaXiuqian MuAndrew R. JacksonShin HeesunCharles A. WhittakerEuan R. BrownNansheng ChenPatrick CormierPatrick CormierRalph HaygoodPedro MartinezR. Andrew CameronD. WangWendy S. BeaneEric H. DavidsonChristie KovarHemant KelkarCharles A. EttensohnSham V. NairRobert L. MorrisStefan C. MaternaMichael C. ThorndykeRichard A. GibbsDan O Mellottsubject
MaleMESH: Signal TransductionMESH: Sequence Analysis DNAMESH : Transcription FactorsMESH : Calcification PhysiologicGenomeMESH : Proteins0302 clinical medicineMESH : Embryonic DevelopmentMESH: Gene Expression Regulation DevelopmentalInnateMESH: Embryonic DevelopmentDevelopmentalNervous System Physiological PhenomenaMESH: AnimalsMESH: Proteins[SDV.BDD]Life Sciences [q-bio]/Development BiologyComplement ActivationComputingMilieux_MISCELLANEOUSMESH: Evolution MolecularMESH : Strongylocentrotus purpuratusGenetics0303 health sciencesMESH: Nervous System Physiological PhenomenaMultidisciplinaryGenomebiologyMedicine (all)MESH: Immunologic FactorsGene Expression Regulation DevelopmentalGenome projectMESH: Transcription FactorsMESH : Immunity InnateMESH : Complement ActivationMESH: GenesBacterial artificial chromosome (BAC)DeuterostomesStrongylocentrotus purpuratusVertebrate innovationsEchinodermMESH : Nervous System Physiological Phenomenaembryonic structuresMESH: Cell Adhesion MoleculesMESH : GenesMESH: Immunity InnateSequence AnalysisSignal TransductionMESH: Computational BiologyGenome evolutionMESH: Complement ActivationSequence analysisEvolutionMESH: Strongylocentrotus purpuratusMESH : MaleEmbryonic DevelopmentMESH : Immunologic FactorsArticleMESH: Calcification PhysiologicCalcificationMESH : Cell Adhesion MoleculesEvolution Molecular03 medical and health sciencesCalcification PhysiologicAnimalsImmunologic FactorsMESH: Genome[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular BiologyMESH : Evolution MolecularPhysiologicGeneStrongylocentrotus purpuratus[ SDV.BBM ] Life Sciences [q-bio]/Biochemistry Molecular Biology030304 developmental biologyMESH : Signal TransductionBacterial artificial chromosomeImmunityMolecularComputational BiologyProteinsAnimals; Calcification Physiologic; Cell Adhesion Molecules; Complement Activation; Computational Biology; Embryonic Development; Evolution Molecular; Gene Expression Regulation Developmental; Genes; Immunity Innate; Immunologic Factors; Male; Nervous System Physiological Phenomena; Proteins; Signal Transduction; Strongylocentrotus purpuratus; Transcription Factors; Genome; Sequence Analysis DNA; Medicine (all); MultidisciplinaryDNASequence Analysis DNAbiology.organism_classificationStrongylocentrotus purpuratusImmunity InnateMESH: MaleGene Expression RegulationGenesMESH : AnimalsMESH : Gene Expression Regulation DevelopmentalMESH : GenomeCell Adhesion Molecules030217 neurology & neurosurgeryMESH : Computational BiologyTranscription FactorsMESH : Sequence Analysis DNAdescription
We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus , a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-11-10 |