6533b86dfe1ef96bd12c972b
RESEARCH PRODUCT
Parvalbumin-containing interneurons do not innervate granule cells in the olfactory bulb
Carlos CrespoJosé Miguel Blasco-ibáñezAna Isabel Marqués-maríFrancisco José Martínez-guijarrosubject
MaleOlfactory systemgenetic structuresInterneuronInhibitory postsynaptic potentialInterneuronsPostsynaptic potentialNeural PathwaysNeuropilmedicineAnimalsRats WistarMicroscopy Immunoelectrongamma-Aminobutyric Acidbiologymusculoskeletal neural and ocular physiologyGeneral NeuroscienceOlfactory BulbRatsOlfactory bulbSmellParvalbuminsmedicine.anatomical_structurenervous systemSynapsesbiology.proteinGABAergicNeuroscienceParvalbumindescription
Combining pre-embedding parvalbumin immunostaining and post-embedding immunogold detection of GABA in the olfactory bulb, we investigated whether the parvalbumin-containing GABAergic interneurons of the external plexiform layer exclusively innervate principal cells, or whether they also establish inhibitory synapses upon GABAergic local neurons such as granule cells. Our results demonstrate that the parvalbumin-containing cells do not contact GABAergic interneurons in the neuropil of the external plexiform layer. On the contrary, their postsynaptic elements were always non-GABAergic principal cells. Although classically it has been accepted that the interneurons of the external plexiform layer could exert a disinhibitory action upon principal cells, via inhibition of GABAergic granule cells, we conclude that they exert a feedback inhibitory action directly and exclusively upon principal cells.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-08-01 | Neuroreport |