6533b86dfe1ef96bd12c97b2
RESEARCH PRODUCT
Exosomes and other extracellular vesicles in neural cells and neurodegenerative diseases
Tadeusz JanasTadeusz JanasAnna M. JanasTeresa JanasMichael H. B. StowellKarolina Sapońsubject
0301 basic medicineNervous systemBiophysicsPresynaptic TerminalsexosomesBiologyBiochemistrySynaptic vesicleExtracellular vesicles03 medical and health sciencessynaptic vesiclesmedicineExtracellularHumansneurodegenerative diseasesNeuronsVesicleneural cellsRNACell Biologymultivesicular bodiesMicrovesiclesCell biology030104 developmental biologymedicine.anatomical_structureFunction (biology)description
The function of human nervous system is critically dependent on proper interneuronal communication. Exosomes and other extracellular vesicles are emerging as a novel form of information exchange within the nervous system. Intraluminal vesicles within multivesicular bodies (MVBs) can be transported in neural cells anterogradely or retrogradely in order to be released into the extracellular space as exosomes. RNA loading into exosomes can be either via an interaction between RNA and the raft-like region of the MVB limiting membrane, or via an interaction between an RNA-binding protein-RNA complex with this raft-like region. Outflow of exosomes from neural cells and inflow of exosomes into neural cells presumably take place on a continuous basis. Exosomes can play both neuro-protective and neuro-toxic roles. In this review, we characterize the role of exosomes and microvesicles in normal nervous system function, and summarize evidence for defective signaling of these vesicles in disease pathogenesis of some neurodegenerative diseases.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-06-01 | Biochimica et Biophysica Acta-Biomembranes |