Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity

6533b86dfe1ef96bd12c97ca

RESEARCH PRODUCT

Identification of modifications in microbial, native tRNA that suppress immunostimulatory activity

Florian Eberle Volker A. Erdmann Alexander H. Dalpke Walter M. Holmes Gérard Keith Steffen Kaiser Mathias Sprinzl Guillaume Bec Tatjana Eigenbrod Mariel-esther Eberle Flavia Botschen Mark Helm Mark Helm Katharina Rimbach Stefanie Gehrig

subject

Immunology Mutant fungi Brief Definitive Report RNA food and beverages virus diseases Context (language use)Biology biochemical phenomena metabolism and nutrition medicine.disease_cause TRNA Methyltransferases Transplantation chemistry.chemical_compound Biochemistry chemistry Transfer RNA medicine Immunology and Allergy Escherichia coli DNA

description

2′-O-methylation of guanosine 18 is a naturally occurring tRNA modification that can suppress immune TLR7 responses.

year	journal	country	edition	language
2012-02-06	The Journal of Experimental Medicine

10.1084/jem.20111044 http://europepmc.org/articles/PMC3280868

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