6533b86dfe1ef96bd12c9d5a

RESEARCH PRODUCT

Surface Marker Analysis by Monoclonal Antibodies: A Valuable Technique in Childhood Acute Myeloid Leukemia

Jörg RitterM. BuddeW.-d. LudwigA. GatzkeFriedhelm HerrmannU. CreutzigGünther Schellong

subject

Acute leukemiaMyeloidAcute myeloblastic leukemiamedicine.drug_classbusiness.industryChildhood Acute Myeloid LeukemiaMyeloid leukemiamedicine.diseaseMonoclonal antibodymedicine.anatomical_structureAntigenhemic and lymphatic diseasesImmunologySurface markermedicinebusiness

description

A considerable number of monoclonal antibodies (MoAbs) with myeloid activity have been described during the last few years (summarized in [1]). These MoAbs have been applied to the study of normal myeloid differentiation, as well as to the surface marker analysis of acute myeloid leukemia (AML) [2–6]. Although there is a strong tendency for morphological differentiation to correspond to surface antigen differentiation of malignant myeloid cells [2, 3], a recent report has failed to correlate the FAB classification system with immunologic categories of AML [6].

yearjournalcountryeditionlanguage
1987-01-01
https://doi.org/10.1007/978-3-642-71213-5_73