6533b86dfe1ef96bd12c9db8
RESEARCH PRODUCT
An update on the management and prevention of cytomegalovirus infection following allogeneic hematopoietic stem cell transplantation
Estela GiménezCarlos SolanoPilar RomeroPilar BlancoDavid Navarrosubject
T cellmedicine.medical_treatmentvirus diseasesDiseaseHematopoietic stem cell transplantationBiologyVirologyCytomegalovirus infectionTransplantationReal-time polymerase chain reactionmedicine.anatomical_structureVirologyImmunologymedicineStem cellEx vivodescription
ABSTRACT A significant progress has been made in deciphering critical aspects of the biology and immunology of CMV infection in the allogeneic stem cell transplantation setting. Genetic traits predisposing to active CMV infection and CMV end-organ disease have begun to be delineated. Reliable molecular assays for CMV DNA load quantitation in body fluids have been developed. Elucidation of immune mechanisms affording control of CMV infection will help to improve the management of active CMV infection. Finally, the advent of new CMV-specific antivirals and promising vaccine prototypes as well as the development of fine procedures for large-scale ex vivo generation of functional CMV-specific T cells for adoptive T cell transfer therapies will certainly minimize the negative impact of CMV on survival in these patients.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-02-01 | Future Virology |