β-Thalassemia heterozygote state detrimentally affects health expectation.

6533b86dfe1ef96bd12c9fef

RESEARCH PRODUCT

β-Thalassemia heterozygote state detrimentally affects health expectation.

Massimo Attanasio Walter Sebastiano Pollina Addario Gabriella Dardanoni Aurelio Maggio Rosario Di Maggio Disma Renda Massimiliano Sacco Angela Vitrano Salvatore Scondotto Antonino Giambona Federico Taormina Christian Gluud Andrea Triveri Luciano Graffeo

subject

Liver Cirrhosis medicine.medical_specialty Heterozygote Cirrhosis Thalassemia Minor Thalassemia 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine β-Thalassemia carrier state Life Expectancy Cholelithiasis Internal medicine Internal Medicine Medicine Humans Mortality Thalassemia minor Health expectation business.industry Mood Disorders Carrier state beta-Thalassemia Heterozygote advantage medicine.disease Hospitalization Thalassemia screening Logistic Models Mood disorders Italy Kidney Diseases Kidney disorder business 030215 immunology

description

Background: Thalassemia minor (Tm) individuals, are generally considered healthy. However, the prognosis of Tm individuals has not been extensively studied. The aim of this study was to evaluate the prognosis of Tm versus controls without β-thalassemia carrier state. Methods: A total of 26,006 individuals seeking thalassemia screening at the AOOR Villa Sofia-V. Cervello, Palermo (Italy) were retrospectively studied. Logistic penalised regression model was used to estimate risk of potential complications and survival techniques were used to study mortality. Results: We identified a total of 4943 Tm and 21,063 controls. Tm was associated with significantly higher risks of hospitalisation for cirrhosis (OR 1·94, 95% CI 1·30 to 2·90, p = 0·001), kidney disorders (OR 2·11, 95% CI 1·27 to 3·51, p = 0·004), cholelithiatis (OR 1·39, 95% CI 1·08 to 1·79, p = 0·010), and mood disorders (OR 2·08, 95% CI 1·15 to 3·75, p = 0·015). No statistically difference in life expectancy between thalassemia minor and control group was found (HR 1·090, 95% CI 0·777 to 1·555, p < 0·590; log-rank test p =.426). Conclusion: This study shows that Tm affects the prognosis of Tm carriers regarding health expectation. Probably, iron overload and anaemia for several years may be at the basis of these effects.

year	journal	country	edition	language
2018-08-01	European journal of internal medicine

10.1016/j.ejim.2018.06.009 https://pubmed.ncbi.nlm.nih.gov/29934240