6533b86dfe1ef96bd12ca0b5

RESEARCH PRODUCT

Evolution of the human chromosome 13 synteny: Evolutionary rearrangements, plasticity, human disease genes and cancer breakpoints

Polina L. PerelmanVanessa MiliotoNatalia A. SerdyukovaRita ScardinoAnastasia A. ProskuryakovaFrancesca Dumas

subject

0106 biological sciences0301 basic medicineChromosomes Artificial Bacteriallcsh:QH426-470PlasticityEvolutionContext (language use)BiologyBAC probeSettore BIO/08 - AntropologiaSynteny010603 evolutionary biology01 natural sciencesGenomeArticleEvolution Molecular03 medical and health sciencesPaintingBAC probesFISHNeoplasmsGeneticsAnimalsHumansPhylogenyGenetics (clinical)Chromosome 13SyntenyGene RearrangementMammalsBacterial artificial chromosomeAutosomeChromosomes Human Pair 13Chromosome MappingChromosomeKaryotypelcsh:Genetics030104 developmental biologyEvolutionary biologyHuman synteny

description

The history of each human chromosome can be studied through comparative cytogenetic approaches in mammals which permit the identification of human chromosomal homologies and rearrangements between species. Comparative banding, chromosome painting, Bacterial Artificial Chromosome (BAC) mapping and genome data permit researchers to formulate hypotheses about ancestral chromosome forms. Human chromosome 13 has been previously shown to be conserved as a single syntenic element in the Ancestral Primate Karyotype

yearjournalcountryeditionlanguage
2020-04-01
10.3390/genes11040383http://hdl.handle.net/10447/410931