Alterations in Tau Protein Level and Phosphorylation State in the Brain of the Autistic-Like Rats Induced by Prenatal Exposure to Valproic Acid

6533b86dfe1ef96bd12ca118

RESEARCH PRODUCT

Alterations in Tau Protein Level and Phosphorylation State in the Brain of the Autistic-Like Rats Induced by Prenatal Exposure to Valproic Acid

Magdalena Cieślik Agata Adamczyk Agnieszka Dominiak Magdalena Gąssowska-dobrowolska Agnieszka Kolasa-wołosiuk Kristina Friedland

subject

0301 basic medicine Dendritic spine Hippocampus lcsh:Chemistry 0302 clinical medicine Pregnancy Tubulin Phosphorylation lcsh:QH301-705.5 Spectroscopy Valproic Acid biology ERK1/2 Chemistry autism spectrum disorders (ASD)valproic acid (VPA)Brain General Medicine Immunohistochemistry Computer Science Applications medicine.anatomical_structure Cerebral cortex Maternal Exposure Prenatal Exposure Delayed Effects Female Disease Susceptibility medicine.drug Signal Transduction medicine.medical_specialty CDK5 Tau protein tau Proteins Catalysis Article Inorganic Chemistry 03 medical and health sciences Internal medicine mental disorders medicine Animals Physical and Theoretical Chemistry Autistic Disorder Molecular Biology Cyclin-dependent kinase 5 GSK-3β Valproic Acid Organic Chemistry α/β-tubulin Rats Enzyme Activation 030104 developmental biology Endocrinology lcsh:Biology (General)lcsh:QD1-999 MAP-Tau Chromatolysis Synaptic plasticity biology.protein Akt/mTOR signalling 030217 neurology & neurosurgery Biomarkers

description

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficient social interaction and communication besides repetitive, stereotyped behaviours. A characteristic feature of ASD is altered dendritic spine density and morphology associated with synaptic plasticity disturbances. Since microtubules (MTs) regulate dendritic spine morphology and play an important role in spine development and plasticity the aim of the present study was to investigate the alterations in the content of neuronal α/β-tubulin and Tau protein level as well as phosphorylation state in the valproic acid (VPA)-induced rat model of autism. Our results indicated that maternal exposure to VPA induces: (1) decrease the level of α/β-tubulin along with Tau accumulation in the hippocampus and cerebral cortex

year	journal	country	edition	language
2021-03-01	International Journal of Molecular Sciences

10.3390/ijms22063209 http://europepmc.org/articles/PMC8004207