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RESEARCH PRODUCT
Interictal Executive Dysfunction in Migraineurs Without Aura: Relationship With Duration and Intensity of Attacks
Cecilia CamardaD. ReccaCarmela PipiaRosolino CamardaRoberto Monasterosubject
AdultMaleMigraine without Auramedicine.medical_specialtyTime FactorsAuraNeuropsychological TestsAudiology03 medical and health sciences0302 clinical medicineExecutive functions migraine characteristics migraine neuropsychologymedicineHumans030212 general & internal medicineAge of OnsetPsychiatrybusiness.industryNeuropsychologyCognitionGeneral Medicinemedicine.diseaseExecutive functionsHyperintensityCognitive testCross-Sectional StudiesMigraineFemaleSettore MED/26 - NeurologiaNeurology (clinical)Cognition Disordersbusiness030217 neurology & neurosurgeryExecutive dysfunctiondescription
Subjects with migraine are at increased risk of subcortical white matter lesions (WML). Reports of cognitive testing in adults with migraine have yielded inconsistent results. We performed a cross-sectional study to assess whether migraine without aura (MwA) is associated with impairment in executive functioning, a typical cognitive correlate of subcortical WML. Forty-five subjects with MwA and 90 controls, matched for age and education, underwent a cognitive battery of tests evaluating executive functions. The following migraine characteristics were collected: age at onset and length of migraine history, and frequency, duration and intensity of attacks. Subjects with MwA performed significantly lower than controls in tests evaluating complex, multifactorial executive functions. After multiple adjustments, the duration and intensity of migraine attacks significantly predicted cognitive disturbances. In the interictal phase of MwA there is evidence of mild executive dysfunction. The cumulative effects of repeated migraine attacks on prefronto-cerebellar loop probably account for our results.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-10-01 | Cephalalgia |