6533b86dfe1ef96bd12ca132
RESEARCH PRODUCT
Anti-poliovirus activity of Nerium oleander aqueous extract
F. Lukmanul HakkimDavid ColluGiuseppina SannaThomas A. EfferthSilvia MadedduAlessandra SerraLuay Rashansubject
Aqueous extractApocynaceaeTraditional medicine010405 organic chemistryNerium oleanderPoliovirusvirusesOrganic ChemistryPlant ScienceBiologymedicine.disease_causebiology.organism_classification01 natural sciencesBiochemistry0104 chemical sciencesAnalytical Chemistry010404 medicinal & biomolecular chemistryOrnamental plantmedicinedescription
Nerium oleander (NO), a member of the Apocynaceae family, is an ornamental plant. In this study, we evaluated the antiviral activity of hot and cold extract of NO against six different viruses such as herpes simplex virus type 1 (HSV-1), polio virus type 1 (Sb-1), vesicular stomatitis virus (VSV), reovirus type-1 (Reo-1), human immunodeficiency virus type-1 (HIV-1), and yellow fever virus (YFV). Interestingly the results of plaque reduction assay demonstrated that both, hot extract and cold extract (breastin) of NO inhibited Sb-1 viral infection. In order to identify the mechanism by which NO exerts its antiviral activity, the virucidal effect, the time of addition and the adsorption assay were carried out. Results demonstrated that NO exerts its effect after infection period, particularly during the first two hours post infection.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-03-25 |