6533b86dfe1ef96bd12ca1bc
RESEARCH PRODUCT
Influence of agents that act on DNA and RNA synthesis on the activity of poly(ADP-Rib) polymerase
Rudolf K. ZahnW. E. G. Müllersubject
SpermidineShowdomycinSpermineCoturnixOviductsShowdomycinCellular and Molecular Neurosciencechemistry.chemical_compoundNAD+ NucleosidaseEthidiumpolycyclic compoundsAnimalsN-Glycosyl HydrolasesMolecular BiologyPolymeraseCell NucleusPharmacologychemistry.chemical_classificationbiologyAdenineRifamycinDNATemplates GeneticCell BiologyMolecular biologySpermidineKineticsEnzymechemistryBiochemistrybiology.proteinRNAMolecular MedicineFemaleSpermineNAD+ kinaseFormycinsDNAdescription
The activity of poly(ADP-Rib) polymerase is enhanced in the presence of spermine and spermidine. Among the adenosine-like antibiotics tested, only formycin B and showdomycin cause an inhibition of the enzyme, which is competitive to NAD. The activity of poly(ADP-Rib) polymerase is not reduced by rifamycin, alpha-amanitin and 2-phenylethanol.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1975-09-01 | Experientia |