6533b86dfe1ef96bd12ca24a
RESEARCH PRODUCT
Stem Cell Populations and Regenerative Potential in Chronic Inflammatory Lung Diseases
Alberto FucarinoFabio BucchieriLuigi RizzutoFrancesco CappelloAntonio NotoGiovanni ZummoAlessandro Pitruzzellasubject
Pathologymedicine.medical_specialtyLungExacerbationCellular differentiationOrgan dysfunctionStem cells airways epithelial mesenchymal trophic unit histogenesisInflammationDiseaserespiratory systemBiologymedicine.anatomical_structureDevelopmental NeuroscienceImmunologymedicinemedicine.symptomStem cellTissue homeostasisDevelopmental Biologydescription
Several acute and chronic inflammatory pathologies of the lung are accompanied by structural modifications of airway mucosa that vary depending on the severity, duration and type of the disease. These morphological changes, that determine organ dysfunction, are not always reversible. Indeed, the cycle of injury and repair, influencing airway wall re- generation, may sometimes break off and an exacerbation of the pathology may occur. The mechanisms at the base of airway remodelling during inflammation have been widely studied and numerous evidences indicate that the molecular dialogue among the cells of the mucosa has an essential role in orchestrating cell differentiation and tissue repair. In this review, we revise old notions on pulmonary morphology at the light of some of the most recent discoveries concerning stem cell differentiation, tissue homeostasis and organ regeneration of the lung.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-05-11 |