6533b86dfe1ef96bd12ca81f

RESEARCH PRODUCT

The relation between neuronal chloride transporter activities, GABA inhibition, and neuronal activity

Werner Kilb

subject

Action potentialChemistryBiophysicsExcitatory postsynaptic potentialPremovement neuronal activityGABAergicDepolarizationReversal potentialInhibitory postsynaptic potentialShunting inhibition

description

Abstract The intracellular chloride concentration [Cl−]i in neurons is regulated by a set of transmembrane transporters, with the Cl−-loader NKCC1 and the Cl−-extruder KCC2 as most relevant members. The expression of these transporters is tightly regulated, with the general trend that KCC2 expression is low in immature neurons, which are thus characterized by a high [Cl−]i. As [Cl−]i is the main factor determining the polarity of GABAergic responses, such a high [Cl−]i is related to depolarizing GABAergic responses. However, depolarizing GABAergic responses are not per se excitatory, but can also contribute to shunting inhibition. The excitatory/inhibitory action of GABAergic responses is mainly determined by the relation between GABA reversal potential and action potential threshold, with additional conditions, like spatial confounds or voltage dependent currents, also contributing to this distinction. Accordingly, both excitatory and inhibitory GABAergic responses have been observed in immature neurons.

yearjournalcountryeditionlanguage
2020-01-01
https://doi.org/10.1016/b978-0-12-815318-5.00003-0