6533b86dfe1ef96bd12caa35
RESEARCH PRODUCT
Multiple roles forHoxgenes in segment-specific shaping of CNS lineages
Gerhard M. TechnauAna Rogulja-ortmannsubject
Central Nervous SystemGeneticsCellular differentiationGenes HomeoboxApoptosisCell DifferentiationBiologyCell fate determinationNeuromerebiology.organism_classificationEmbryonic stem cellNeural stem cellCell biologyDrosophila melanogasterInsect ScienceAnimalsDrosophila melanogasterHox geneNeural cellCell Proliferationdescription
In this article we highlight some of the recently accumulating evidence showing that Hox genes are involved at different steps during the development of neural cell lineages to control segmental patterning of the CNS. In addition to their well-known early role in establishing segmental identities, Hox genes act on neural stem cells and their progeny at various stages during embryonic and postembryonic development to control proliferation, cell fate and/or apoptosis in a segment-specific manner. This leads to differential shaping of serially homologous lineages and thus to structural diversification of segmental CNS units (neuromeres) in adaptation to their specific functional tasks in processing sensory information and generation of motor patterns.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-11-01 | Fly |