6533b86dfe1ef96bd12caa74
RESEARCH PRODUCT
Internuclear ophthalmoplegia of abduction: clinical and electrophysiological data on the existence of an abduction paresis of prenuclear origin.
Hanns Christian HopfFrank ThömkeGünter Krämersubject
Malegenetic structuresInternuclear ophthalmoplegiaFunctional LateralityOculomotor nucleusAbducens NerveOculomotor NervePonsmedicineHumansAbducens nerveParesisAgedOphthalmoplegiaBlinkingOculomotor nervebusiness.industryReticular FormationMedial rectus muscleAnatomyParamedian pontine reticular formationMiddle AgedMedial longitudinal fasciculusmedicine.diseasebody regionsElectrophysiologyPsychiatry and Mental healthElectrooculographymedicine.anatomical_structureSurgeryFemaleNeurology (clinical)medicine.symptombusinessResearch Articledescription
Three patients showed unilateral and five bilateral abduction paresis. Five had associated adduction nystagmus of the contralateral eye. Electrophysiological testing of masseter and blink reflexes indicated an ipsilateral rostral pontine or mesencephalic lesion, and excluded a lesion of the infranuclear portion of the abducens nerve. Abduction paresis was attributed to impaired inhibition of the tonic resting activity of the antagonistic medial rectus muscle. The prenuclear origin of the disorder is based on morphological and neurophysiological evidence of an ipsilateral inhibitory connection between the paramedian pontine reticular formation and the oculomotor nucleus running close to but separated from the medial longitudinal fasciculus.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-02-01 | Journal of neurology, neurosurgery, and psychiatry |