6533b86dfe1ef96bd12cab2c
RESEARCH PRODUCT
Straightforward Stereoselective Access to Cyclic Peptidomimetics
Santos FusteroLaia AlbertNatalia MateuJosé Luis Aceñasubject
chemistry.chemical_classificationCyclic compoundDipeptideChemistryStereochemistryMolecular MimicryOrganic ChemistryGlycineStereoisomerismDipeptidesTripeptideRing (chemistry)Peptides CyclicChemical synthesisCyclic peptideLactoneschemistry.chemical_compoundCyclizationEthanolaminesLactamLactonedescription
The preparation of cyclic dipeptide mimetics from chiral imino lactones derived from (R)-phenylglycinol is described. Key steps of the synthetic route included the fully stereoselective construction of a quaternary center, the formation of six-, seven-, or eight-membered lactams by means of an RCM cyclization, and the introduction of a new amino group within the lactam ring. The synthesis of a tripeptide mimetic is also reported.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-01-01 |