6533b86efe1ef96bd12cac47

RESEARCH PRODUCT

Development of tolerance to the antiaggressive effects of morphine

Marta Rodríguez-ariasJosé MiñarroVicente M. Simón

subject

MalePharmacologyDose-Response Relationship DrugMorphineInjury controlAccident preventionbusiness.industryPoison controlDrug ToleranceMotor ActivitySuicide preventionOccupational safety and healthAggressionMicePsychiatry and Mental healthAnesthesiaInjury preventionExploratory BehaviorMorphinemedicineAnimalsSocial BehaviorbusinessAgonistic Behaviormedicine.drug

description

Many reports have demonstrated that there is a development of tolerance to many effects produced by morphine. This study was conducted with the aim of determining whether the antiaggressive actions of morphine develop tolerance after chronic administration. Acute morphine administration produced antiaggressive effects which disappeared after chronic (7 days) treatment in isolated mice. An increase in non-social exploration was observed, representing morphine-induced hyperactivity, after acute treatment, which was not present after chronic administration. In conclusion, there is a development of tolerance to the antiaggressive and motor effects of morphine. Language: en

yearjournalcountryeditionlanguage
2001-08-04Behavioral Pharmacology
https://doi.org/10.1097/00008877-200105000-00008