Bioelectrochemical monitoring of soluble guanylate cyclase inhibition by the natural β-carboline canthin-6-one

6533b86efe1ef96bd12cb263

RESEARCH PRODUCT

Bioelectrochemical monitoring of soluble guanylate cyclase inhibition by the natural β-carboline canthin-6-one

Regina Rodrigo Erwan Poupon Jean-didier Maréchal Alain Fournet Bruno Figadère Antonio Doménech-carbó Gerardo Cebrián-torrejón Gerardo Cebrián-torrejón

subject

0301 basic medicine GUCY1B3 010405 organic chemistry Stereochemistry Chemistry Alkaloid Organic Chemistry GUCY1A3 01 natural sciences Solution phase 0104 chemical sciences Analytical Chemistry Inorganic Chemistry 03 medical and health sciences 030104 developmental biology Canthin-6-one Voltammetry Spectroscopy Guanylate cyclase Cysteine

description

Abstract The inhibition of soluble guanylate cyclase (sGC) by canthin-6-one alkaloid ( L1 ) is presented and the mechanism of deactivation is studied using solution phase and voltammetry of microparticles methodologies. Possible inhibition pathways: oxidation of Fe 2+ to Fe 3+ coupled to reduction of the naphthyridone motif present by the canthin-6-one and coordinating or reacting of L1 with cysteine units of sGC, are balanced.

year	journal	country	edition	language
2017-04-01	Journal of Molecular Structure

https://doi.org/10.1016/j.molstruc.2016.12.016

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