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RESEARCH PRODUCT
Deoxycholic Acid Methyl Ester — a Novel Bacterial Metabolite of Cholic Acid
Rainer HammannR. Edenhardersubject
biologyBile acidmedicine.drug_classMetaboliteDeoxycholic acidCholic acidbiology.organism_classificationApplied Microbiology and BiotechnologyMicrobiologyMicrobiologychemistry.chemical_compoundfluids and secretionschemistryBiochemistryLactobacillusmedicineEubacteriumBacteroidesEcology Evolution Behavior and SystematicsBacteriadescription
Summary Methyl deoxycholate was identified as a novel bacterial metabolite of cholate, produced anaerobically by strains of most saccharolytic Bacteroides species ( B. distasonis, B. eggerthii, B. fragilis, B. incommunis, B. thetaiotaomicron, B. uniformis, B. variabilis, B. vulgatus , and unnamed species). It was also detected with a few strains of Eubacterium and Lactobacillus species. Among 2476 freshly isolated human fecal cultures the frequency of carboxyl group esterification was comparable with that of 7α-dehydroxylation (92 versus 102 cultures). Both activities were, however, lost for unknown reasons after serial transfers. Two of ten mixed fecal cultures tested esterified 3α,7α- or 3α,12α-dihydroxy bile acids at C-24, but not cholate when grown anaerobically.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1985-06-01 | Systematic and Applied Microbiology |